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Research

Research Programs

 

Scientifically-focused, highly-collaborative research programs with active members are essential attributes of National Cancer Institute-designated cancer centers. The Institute highlights the importance of these attributes in the guidelines for the NCI P30 CCSG:

“Cancer centers foster cancer-focused research, in part through the creation of formal scientific Programs. A Program comprises the activities of a group of investigators who share common scientific interests and goals and participate in competitively-funded research. Programs should be highly interactive and lead to exchange of information, experimental techniques, and ideas that enhance the individual productivity of scientists and often result in collaborations and joint publications. Ultimately, the success of Programs is measured by scientific excellence and the emergence of productive collaborations.”

Applicants will be assigned to a Program that best aligns with their primary research interests. Scientific goals are listed under each program. The “Non-Aligned” category is for investigators who engage in cancer research that is not related to one of the programs below:

Cancer Prevention and Control Research

The mission of the Program is to build a robust, transdisciplinary cancer prevention and control research and training program to reduce the burden of cancer in Oklahoma’s most vulnerable populations, with special foci on the American Indian and rural populations. The program has several goals, including:

(1) Health Disparities: To develop and employ novel community engagement strategies to overcome persistent cancer health disparities that affect American Indians and rural populations.

(2) Tobacco Control: To examine basic mechanisms underlying tobacco initiation, maintenance, cessation, and relapse, and to develop and evaluate novel tobacco treatments. 

(3) Chemoprevention: To apply natural, synthetic or biological agents to reverse or suppress premalignant lesion progression to invasive disease in high-risk cohorts in Oklahoma and nationally.

Gynecologic Cancers Research

The mission of the Program is to raise the standard of care and improve clinical outcomes for women with gynecologic cancers. Program members collaborate in thematically-focused, team-based projects in order:

(1) To discover and interrogate molecular mechanisms central to carcinogenesis in gynecologic cancers in order to develop targeted approaches to improve prevention, early detection and treatment.

(2) To advance novel discoveries into therapeutic strategies in gynecologic cancers

through the design and conduct of early-phase clinical trials.

(3) To impact the Stephenson Cancer Center catchment area and the nation through the design and conduct of clinical trials that improve patient outcomes.

Preclinical Cancer Research

The mission of the Program is to promote and accelerate scientific discovery and development of ideas through the translational continuum in order to impact the prevention, diagnosis and treatment of cancer, both within the Stephenson Cancer Center's catchment area and nationally. Goals of the program include:

(1) To understand the genetic, epigenetic and signaling mechanisms that drive tumor growth, progression and responses to therapy.

(2) To develop novel strategies and tools to improve cancer prevention, early detection and treatment, with a focus in nanomedicine and imaging.

(3) To accelerate the translation of promising ideas into novel therapeutic strategies for improving patient outcomes through collaborative, transdisciplinary, team-based science.

Non-Aligned

Non-Aligned members engage in cancer-related research that is not related to the Scientific Goals of a research program. Affiliate and Clinical Members in the Stephenson Cancer Center may be Non-Aligned (i.e., not have research program appointments).

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